Peptide fibrillization

DOI: 10.1002/anie.200700861
PMID: 17935097

Authors: Ian Hamley (University of Reading, Diamond Light Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition , VOL 46 (43) , PAGES 8128 - 8147

State: Published (Approved)
Published: October 2007

Abstract: The fibrillization of peptides is relevant to many diseases based on the deposition of amyloids. The formation of fibrils is being intensively studied, especially in terms of nanotechnology applications, where fibrillar peptide hydrogels are used for cell scaffolds, as supports for functional and responsive biomaterials, biosensors, and nanowires. This Review is concerned with fundamental aspects of the self-assembly of peptides into fibrils, and discusses both natural amyloid-forming peptides and synthetic materials, including peptide fragments, copolymers, and amphiphiles.

Journal Keywords: Amyloids ; Biomaterials ; Peptides ; Self-Assembly ; Soft Matter

Subject Areas: Chemistry


Technical Areas: