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A Highly Oriented Cubic Phase Formed by Lipids under Shear

DOI: 10.1021/ja2053336 DOI Help

Authors: Annela Seddon (University of Bristol; Bristol Centre for Functional Nanomaterials) , Gudrun Lotze (University of Reading) , Tomas S. Plivelic (Lund University) , Adam M. Squires (University of Reading)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The American Chemical Society , VOL 133 , PAGES 13860 - 13863

State: Published (Approved)
Published: September 2011

Abstract: We demonstrate the formation of a macroscopically oriented inverse bicontinuous cubic (QII) lipid phase from a sponge (L3) phase by controlled hydration during shear flow. The L3 phase was the monoolein/butanediol/water system; the addition of water reduces the butanediol concentration, inducing the formation of a diamond (QIID) cubic phase, which is oriented by the shear flow. The phenomenon was reproduced in both capillary and Couette geometries, indicating that this represents a robust general route for the production of highly aligned bulk QII samples, with applications in nanomaterial templating and protein research.

Subject Areas: Physics

Technical Areas: