Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and their Small-Molecule Model Compounds

DOI: 10.1021/acs.cgd.7b00221

Authors: Andrea Perrin (Durham University) , Melissa J. Goodwin (Durham University) , Osama M Musa (Ashland Inc.) , David Berry (University Boulevard) , Philip Corner (University Boulevard) , Katharina Edkins (University Boulevard) , Dmitry S. Yufit (Durham University) , Jonathan W. Steed (Durham University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystal Growth & Design , VOL 17 , PAGES 3236–3249

State: Published (Approved)
Published: April 2017
Diamond Proposal Number(s): 8682

Abstract: The solution hydration behavior of a series of lactam-based kinetic clathrate hydrate inhibitors (KHIs) has been studied in order to determine mechanistic insight into their KHI performance. IR and 1H NMR spectroscopic titration data were compared across a series of mono- and bis(lactam) model compounds, and solid-phase hydration behavior was examined by Dynamic Vapour Sorption. The structures of several of the model compounds have been investigated by X-ray crystallography. The work reveals insight into the very low crystallinity and high hygroscopicity of these materials which is linked to their performance as KHIs. Analysis of water binding in sour gas systems, containing H2S and CO2, reveals no effect on the water affinity of the lactams suggesting that sour gas components do not inhibit KHI performance, but rather promote clathrate hydrate formation.

Journal Keywords: clathrate hydrate; kinetic hydrate inhibitor; lactam, pyrrolidone

Subject Areas: Chemistry


Instruments: I19-Small Molecule Single Crystal Diffraction