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Copper-Catalyzed Synthesis and Applications of Yndiamides

DOI: 10.1002/anie.201706915 DOI Help

Authors: Edward Alexander Anderson (University of Oxford) , Steven Mansfield (University of Oxford) , Kirsten Christensen (University of Oxford) , Amber Thompson (University of Oxford) , Kai Ma (University of Oxford) , Michael Jones (University of Oxford) , Aroonroj Mekareeya (University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition

State: Published (Approved)
Published: September 2017
Diamond Proposal Number(s): 13639

Abstract: The first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established via copper (I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition metal- and acid-catalyzed transformations, which afford a wide variety of 1,2-diamide functionalized products.

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 08/09/2017 09:05

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