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Changes to DPPC Domain Structure in the Presence of Carbon Nanoparticles

DOI: 10.1021/acs.langmuir.7b01077 DOI Help

Authors: Alan Sheridan (Birkbeck College, University of London) , Jonathan M. Slater (Birkbeck College, University of London) , Thomas Arnold (Diamond Light Source) , Richard A. Campbell (Institut Laue-Langevin) , Katherine C. Thompson (Birkbeck, University of London)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Langmuir

State: Published (Approved)
Published: September 2017

Open Access Open Access

Abstract: DPPC (dipalmitoylphosphatidylcholine) is a disaturated lipid capable of forming closely packed monolayers at the air–liquid interface of the lung and allows the surface tension within the alveoli to reduce to almost zero and thus prevent alveolar collapse. Carbon nanoparticles are formed in natural and man-made combustion events, including diesel engines, and are capable of reaching the alveolar epithelium during breathing. In this work, we have used Brewster angle microscopy and neutron reflectivity to study the effect of differing concentrations of carbon nanoparticles on the structure of DPPC monolayer as the monolayer is subject to compression and expansion. The results show that the inclusion of carbon nanoparticles within a DPPC monolayer affects the formation and structure of the lipid domains. The domains lose their circular structure and show a crenated structure as well as a reduction in overall size of the domains. This change in structure is also evident following expansion of the lipid monolayer, suggesting that some carbon nanoparticles may remain associated with the monolayer. This observation could have an important implication regarding the removal of nanosized airborne pollutants from the human lung.

Subject Areas: Biology and Bio-materials, Chemistry

Diamond Offline Facilities: Spectroscopic Imaging Ellipsometer / Brewster Angle Microscope (Nanofilm EP3SE)
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