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Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

DOI: 10.1039/C7SM01620D DOI Help

Authors: Monika Kluzek (Universite de Strasbourg) , Arwen I. I. Tyler (Imperial College London; University of Leeds) , Shiqi Wang (Imperial College London) , Rongjun Chen (Imperial College London) , Carlos M. Marques (Universite de Strasbourg) , Fabrice Thalmann (Universite de Strasbourg) , John Seddon (Imperial College London) , Marc Schmutz (Universite de Strasbourg)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Soft Matter

State: Published (Approved)
Published: September 2017
Diamond Proposal Number(s): 14217

Abstract: Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceuticals and cosmetics applications, and efforts are currently being made to control the encapsulation and release properties of these colloidal objects. We overcome in this work the lack of sensitivity of monoolein cubosomes to pH conditions by using a pH sensitive polymer designed to strongly interact with the lipid structure at low pH. Our cryo-transmission electron microscope (Cryo-TEM) and small-angle X-ray scattering (SAXS) results show that in the presence of the polymer the cubic phase structure is preserved at neutral pH, albeit with a larger cell size. At pH 5.5, in the presence of the polymer, the nanostructure of the cubosome particles is significantly altered, providing a pathway to design pH-responsive cubosomes for applications in drug delivery.

Subject Areas: Chemistry


Instruments: I22-Small angle scattering & Diffraction