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CryoEM-based hybrid modeling approaches for structure determination

DOI: 10.1016/j.mib.2017.10.002 DOI Help

Authors: C. Keith Cassidy (University of Illinois at Urbana-Champaign) , Benjamin A. Himes (University of Pittsburgh School of Medicine) , Zaida Luthey-Schulten (University of Illinois at Urbana-Champaign) , Peijun Zhang (University of Pittsburgh School of Medicine; Diamond Light Source; University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Current Opinion In Microbiology , VOL 43 , PAGES 14 - 23

State: Published (Approved)
Published: November 2017

Abstract: Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements of cryoEM-based hybrid modeling, providing an overview of available computational tools and strategies as well as several recent applications.

Subject Areas: Biology and Bio-materials

Technical Areas:

Added On: 08/11/2017 09:40

Discipline Tags:

Structural biology Life Sciences & Biotech

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