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Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment

DOI: 10.1590/S0100-879X2012007500048 DOI Help

Authors: T. R. Rudd (Istituto di Chimica e Biochimica) , A. Hughes (University of Liverpool) , J. Holman (University of Liverpool) , V. Solari , E. De Oliveira Ferreira (Universidade Federal do Rio de Janeiro) , R. M. Cavalcante Pilotto Domingues (Universidade Federal do Rio de Janeiro) , E. A. Yates (University of Liverpool)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Brazilian Journal Of Medical And Biological Research , VOL 45 , PAGES 386 - 391

State: Published (Approved)
Published: May 2012
Diamond Proposal Number(s): 7113 , 5685

Open Access Open Access

Abstract: Heparan sulphate (HS) and the related polysaccharide, heparin, exhibit conformational and charge arrangement properties, which provide a degree of redundancy allowing several seemingly distinct sequences to exhibit the same activity. This can also be mimicked by other sulphated polysaccharides, both in overall effect and in the details of interactions and structural consequences of interactions with proteins. Together, these provide a source of active compounds suitable for further development as potential drugs. These polysaccharides also possess considerable size, which bestows upon them an additional useful property: the capability of disrupting processes comprising many individual interactions, such as those characterising the attachment of microbial pathogens to host cells. The range of involvement of HS in microbial attachment is reviewed and examples, which include viral, bacterial and parasitic infections and which, in many cases, are now being investigated as potential targets for intervention, are identified.

Journal Keywords: Heparan sulfate; Biosynthesis; Structure-function; Microbial attachment

Subject Areas: Biology and Bio-materials, Medicine, Chemistry

Instruments: B23-Circular Dichroism

Added On: 08/11/2017 16:41

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