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A biomimetic tumor tissue phantom for validating diffusion-weighted MRI measurements

DOI: 10.1002/mrm.27016 DOI Help

Authors: Damien J. Mchugh (The University of Manchester; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester) , Feng-lei Zhou (The University of Manchester; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester; The University of Manchester) , Ian Wimpenny (The University of Manchester) , Gowsihan Poologasundarampillai (The University of Manchester; Research Complex at Harwell) , Josephine H. Naish (The University of Manchester) , Penny L. Hubbard Cristinacce (The University of Manchester) , Geoffrey J. M. Parker (The University of Manchester; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Magnetic Resonance In Medicine , VOL 11

State: Published (Approved)
Published: November 2017
Diamond Proposal Number(s): 15507

Open Access Open Access

Abstract: Purpose: To develop a biomimetic tumor tissue phantom which more closely reflects water diffusion in biological tissue than previously used phantoms, and to evaluate the stability of the phantom and its potential as a tool for validating diffusion-weighted (DW) MRI measurements. Methods: Coaxial-electrospraying was used to generate micron-sized hollow polymer spheres, which mimic cells. The bulk structure was immersed in water, providing a DW-MRI phantom whose apparent diffusion coefficient (ADC) and microstructural properties were evaluated over a period of 10 months. Independent characterization of the phantom's microstructure was performed using scanning electron microscopy (SEM). The repeatability of the construction process was investigated by generating a second phantom, which underwent high resolution synchrotron-CT as well as SEM and MR scans. Results: ADC values were stable (coefficients of variation (CoVs) < 5%), and varied with diffusion time, with average values of 1.44 ± 0.03 µm2/ms (Δ = 12 ms) and 1.20 ± 0.05 µm2/ms (Δ = 45 ms). Microstructural parameters showed greater variability (CoVs up to 13%), with evidence of bias in sphere size estimates. Similar trends were observed in the second phantom. Conclusion: A novel biomimetic phantom has been developed and shown to be stable over 10 months. It is envisaged that such phantoms will be used for further investigation of microstructural models relevant to characterizing tumor tissue, and may also find application in evaluating acquisition protocols and comparing DW-MRI-derived biomarkers obtained from different scanners at different sites.

Journal Keywords: tumor microstructure; diffusion MRI; biomimetic phantoms; hollow microspheres; coaxial electrospraying

Subject Areas: Biology and Bio-materials, Medicine


Instruments: I13-2-Diamond Manchester Imaging

Documents:
McHugh_et_al-2017-Magnetic_Resonance_in_Medicine.pdf