Rapid continuous antisolvent crystallization of multi-component systems

DOI: 10.1021/acs.cgd.7b01105

Authors: Syed A. Raza (University of Strathclyde) , Ulrich Schacht (University of Strathclyde) , Vaclav Svoboda (University of Strathclyde) , Darren P. Edwards (University of Strathclyde) , Alastair J. Florence (University of Strathclyde) , Colin R. Pulham (University of Edinburgh) , Jan Sefcik (University of Strathclyde) , Iain D. H. Oswald (University of Strathclyde)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystal Growth & Design

State: Published (Approved)
Published: November 2017
Diamond Proposal Number(s): 3907 , 7150

Abstract: This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.

Subject Areas: Chemistry, Biology and Bio-materials


Instruments: I11-High Resolution Powder Diffraction , I19-Small Molecule Single Crystal Diffraction