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Rapid continuous antisolvent crystallization of multi-component systems
Authors:
Syed A.
Raza
(University of Strathclyde)
,
Ulrich
Schacht
(University of Strathclyde)
,
Vaclav
Svoboda
(University of Strathclyde)
,
Darren P.
Edwards
(University of Strathclyde)
,
Alastair J.
Florence
(University of Strathclyde)
,
Colin R.
Pulham
(University of Edinburgh)
,
Jan
Sefcik
(University of Strathclyde)
,
Iain D. H.
Oswald
(University of Strathclyde)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Crystal Growth & Design
State:
Published (Approved)
Published:
November 2017
Diamond Proposal Number(s):
3907
,
7150
Abstract: This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.
Subject Areas:
Chemistry,
Biology and Bio-materials
Instruments:
I11-High Resolution Powder Diffraction
,
I19-Small Molecule Single Crystal Diffraction