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Missing Linker Defects in a Homochiral Metal Organic Framework: Tuning the Chiral Separation Capacity

DOI: 10.1021/jacs.7b10112 DOI Help

Authors: Benjamin Slater (Imperial College London; CSIRO) , Zeru Wang (Imperial College London) , Shanxue Jiang (Imperial College London) , Matthew R. Hill (CSIRO) , Bradley P. Ladewig (Imperial College London)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The American Chemical Society

State: Published (Approved)
Published: November 2017
Diamond Proposal Number(s): 16778

Abstract: Efficient chiral separation remains a very challenging task due to the identical physical and chemical properties of the enantiomers of a molecule. Enantiomers only behave differently from each other in the presence of other chiral species. Homochiral metal organ-ic frameworks have received much attention for their promising enantioseparation properties. However, there are still challenges to overcome in this field such as high enantiomeric separation. Structural defects play an important role in the properties of MOFs and can significantly change the pore architecture. In this work, we introduced missing linker defects into a homochiral metal or-ganic framework [Zn2(bdc)(L-lac)(dmf)] (ZnBLD) and observed an increase in enantiomeric excess for 1-phenylethanol of 35% with the defective frameworks. We adjusted the concentration of monocarboxylic acid ligand L-lactic acid by varying the ratio of Zn2+ to ligand from 0.5 to 0.85mmol. Additionally, a defective framework was synthesized with propanoic acid as modulator. In order to elucidate the correlation between defects and enantiomeric excess, four characterization techniques (FTIR, TGA, 1H NMR and PXRD) were employed. Full width at half maximum analysis (FWHM) was performed on the powder x-ray diffraction traces and showed that the higher concentration of monocarboxylic acid MOFs were isostructural but suffered from increased FWHM values.

Journal Keywords: chiral separation; homochiral metal organic framework; missing linker defects; ZnBLD

Subject Areas: Chemistry, Biology and Bio-materials

Instruments: B23-Circular Dichroism