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Structure and Stability of PEG- and Mixed PEG-Layer-Coated Nanoparticles at High Particle Concentrations Studied In Situ by Small-Angle X-Ray Scattering

DOI: 10.1002/ppsc.201700319 DOI Help

Authors: Florian Schulz (University of Hamburg; The Hamburg Centre for Ultrafast Imaging (CUI)) , Johannes Möller (ESRF – The European Synchrotron; European X-Ray Free-Electron Laser Facility) , Felix Lehmkühler (The Hamburg Centre for Ultrafast Imaging (CUI); Deutsches Elektronen-Synchrotron DESY) , Andrew J. Smith (Diamond Light Source) , Tobias Vossmeyer (University of Hamburg) , Holger Lange (University of Hamburg; The Hamburg Centre for Ultrafast Imaging (CUI)) , Gerhard Grübel (The Hamburg Centre for Ultrafast Imaging (CUI); Deutsches Elektronen-Synchrotron DESY) , Martin A. Schroer (The Hamburg Centre for Ultrafast Imaging (CUI); Deutsches Elektronen-Synchrotron DESY)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Particle & Particle Systems Characterization , VOL 116

State: Published (Approved)
Published: December 2017
Diamond Proposal Number(s): 11192 , 16193

Abstract: Ligand-layer structure and stability of gold nanoparticles (AuNP) coated with α-methoxypoly(ethylene glycol)-ω-(11-mercaptoundecanoate) (PEGMUA) layers and mixed layers of PEGMUA and 11-mercaptoundecanoic acid (MUA) at high AuNP concentrations are studied in situ by small-angle X-ray scattering (SAXS). The thickness of the ligand layer is modified by the molecular weight of the PEG-ligands (2 and 5 kDa), and the PEG-grafting density is decreased by coadsorption of MUA. The response of the conjugates to a pressure of up to 4 kbar is probed. The results indicate strongly hydrated PEG layers at high grafting densities. The stability of the mixed ligand-layer conjugates is lower. This is most probably due to enhanced interparticle PEG–PEG interactions at lower grafting densities. The presented study demonstrates that a detailed structural characterization of polymer ligand layers in situ and in response to external stimuli is possible with SAXS.

Subject Areas: Chemistry, Materials


Instruments: I22-Small angle scattering & Diffraction