SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

DOI: 10.1039/C7BM00515F

Authors: Michael Barrow (University of Liverpool) , Arthur Taylor (University of Liverpool) , Ana M. Fuentes-caparrós (University of Liverpool) , Jack Sharkey (University of Liverpool) , Luke Daniels (University of Liverpool) , Pranab Mandal (University of Liverpool) , B. Kevin Park (MRC Centre for Drug Safety Science, University of Liverpool) , Patricia Murray (Centre for Preclinical Imaging, Institute of Translational Medicine, University of Liverpool) , Matthew Rosseinsky (University of Liverpool) , Dave J. Adams (University of Liverpool)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Biomaterials Science , VOL 6 , PAGES 101 - 106

State: Published (Approved)
Published: November 2017
Diamond Proposal Number(s): 14239

Abstract: Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking.

Subject Areas: Chemistry, Materials, Medicine


Instruments: B18-Core EXAFS

Documents:
C7BM00515F.pdf