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Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?

DOI: 10.1039/C8CE00066B DOI Help

Authors: Stuart R. Kennedy (Durham University) , Christopher D. Jones (Durham University) , Dmitry S. Yufit (Durham University) , Catherine E. Nicholson (Northumbria University) , Sharon J. Cooper (Durham University) , Jonathan W. Steed (Durham University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystengcomm , VOL vol. 2

State: Published (Approved)
Published: February 2018
Diamond Proposal Number(s): 8682

Abstract: We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction