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Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

DOI: 10.1039/C7NR09436A DOI Help

Authors: Inna M. Yasinska (University of Kent) , Giacomo Ceccone (European Commission Joint Research Centre) , Isaac Ojea-Jimenez (European Commission Joint Research Centre) , Jessica Ponti (European Commission Joint Research Centre) , Rohanah Hussain (Diamond Light Source) , Giuliano Siligardi (Diamond Light Source) , Steffen M. Berger (University of Bern) , Elizaveta Fasler-Kan (University of Bern) , Marco Bardelli (Universita’ della Svizzera italiana (USI)) , Luca Varani (Universita’ della Svizzera italiana (USI)) , Walter Fiedler (University Medical Center Hamburg-Eppendorf) , Jasmin Wellbrock (University Medical Center Hamburg-Eppendorf) , Ulrike Raap (University of Oldenburg) , Bernhard F. Gibbs (University of Kent; University of Oldenburg) , Luigi Calzolai (IHCP-European Commission Joint Research Centre) , Vadim V. Sumbayev (University of Kent)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nanoscale , VOL 25

State: Published (Approved)
Published: February 2018
Diamond Proposal Number(s): 12578 , 11373

Open Access Open Access

Abstract: In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Diamond Keywords: Leukaemia

Subject Areas: Medicine, Biology and Bio-materials

Instruments: B23-Circular Dichroism

Added On: 15/03/2018 12:52

Discipline Tags:

Drug Delivery Non-Communicable Diseases Biotechnology Biomaterials Health & Wellbeing Cancer Materials Science Engineering & Technology Nanoscience/Nanotechnology Life Sciences & Biotech

Technical Tags:

Spectroscopy Circular Dichroism (CD)