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Self-assembly and surface behaviour of pure and mixed zwitterionic amphiphiles in a deep eutectic solvent

DOI: 10.1039/C8SM00755A DOI Help

Authors: Adrian Sanchez-fernandez (University of Bath; European Spallation Source) , Georgina L. Moody Moody (University of Bath) , Lloyd C. Murfin (University of Bath) , Thomas Arnold (University of Bath; European Spallation Source; Diamond Light Source) , Andrew J. Jackson (European Spallation Source; Lund University) , Stephen M. King (ISIS Pulsed Neutron & Muon Source) , Simon E. Lewis (University of Bath) , Karen J. Edler (University of Bath)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Soft Matter

State: Published (Approved)
Published: June 2018
Diamond Proposal Number(s): 15584

Open Access Open Access

Abstract: Recent investigations have shown that deep eutectic solvents provide a suitable environment for self-organisation of biomolecules, in particular phospholipids and proteins. However, the solvation of complex lyophilic moieties by deep eutectic solvents still remains unclear. Here we explore the behaviour of zwitterionic surfactants in choline chloride:glycerol eutectic mixture. Dodecyl-2-(trimethylammonio)ethylphosphate and N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (alkyl=dodecyl, tetradecyl) surfactants were investigated by means of surface tension, X-Ray reflectivity and small-angle neutron scattering. These surfactants were found to remain surface active and form globular micelles in deep eutectic solvents. Still, the surface behaviour of these species was found to differ depending on the headgroup and tail structure. The morphology of the micelles also slightly varies between surfactants, demonstrating differences in the packing of individual monomers. The characteristics of mixtures of the dodecyl surfactants is also reported, showing a deviation from ideal mixing associated with attractive interactions between sulfobetaine and phosphocholine headgroups. Such non-ideality results in variation of the surface behaviour and self-assembly of these surfactant mixtures. The results presented here will potentially lead to the development of new alternatives for drug-delivery, protein solubilisation and biosensing through a better fundamental understanding of the behaviour of zwitterionic surfactants in deep eutectic solvents.

Subject Areas: Chemistry, Medicine

Instruments: I07-Surface & interface diffraction

Other Facilities: ISIS