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Effect of SR-microCT radiation on the mechanical integrity of trabecular bone using in situ mechanical testing and digital volume correlation

DOI: 10.1016/j.jmbbm.2018.08.012 DOI Help

Authors: Marta Peña Fernández (University of Portsmouth) , Silvia Cipiccia (Diamond Light Source; University of Strathclyde) , Enrico Dall'ara (University of Sheffield) , Andrew J. Bodey (Diamond Light Source) , Rachna Parwani (University of Portsmouth) , Martino Pani (University of Portsmouth) , Gordon W. Blunn (University of Portsmouth) , Asa H. Barber (University of Portsmouth; London South Bank University) , Gianluca Tozzi (University of Portsmouth)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The Mechanical Behavior Of Biomedical Materials

State: Published (Approved)
Published: August 2018
Diamond Proposal Number(s): 14080

Abstract: The use of synchrotron radiation micro-computed tomography (SR-microCT) is becoming increasingly popular for studying the relationship between microstructure and bone mechanics subjected to in situ mechanical testing. However, it is well known that the effect of SR X-ray radiation can considerably alter the mechanical properties of bone tissue. Digital volume correlation (DVC) has been extensively used to compute full-field strain distributions in bone specimens subjected to step-wise mechanical loading, but tissue damage from sequential SR-microCT scans has not been previously addressed. Therefore, the aim of this study is to examine the influence of SR irradiation-induced microdamage on the apparent elastic properties of trabecular bone using DVC applied to in situ SR-microCT tomograms obtained with different exposure times. Results showed how DVC was able to identify high local strain levels (>10,000 µε) corresponding to visible microcracks at high irradiation doses (~230 kGy), despite the apparent elastic properties remained unaltered. Microcracks were not detected and bone plasticity was preserved for low irradiation doses (~33 kGy), although image quality and consequently, DVC performance were reduced. DVC results suggested some local deterioration of tissue that might have resulted from mechanical strain concentration further enhanced by some level of local irradiation even for low accumulated dose.

Journal Keywords: Bone; X-ray radiation; dose; tissue damage; SR-microCT; digital volume correlation; in situ testing

Subject Areas: Biology and Bio-materials


Instruments: I13-2-Diamond Manchester Imaging