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In situ mechanical behavior of regenerating rat calvaria bones under tensile load via synchrotron diffraction characterization

DOI: 10.21741/9781945291890-19 DOI Help

Authors: Ameni Zaouali (Université de Nantes) , Baptiste Girault (Université de Nantes) , David Gloaguen (Université de Nantes) , Fabienne Jordana (Université de Nantes) , Marie-josé Moya (Université de Nantes) , Pierre-antoine Dubos (Université de Nantes) , Valerie Geoffroy (Université de Nantes) , Matthias Schwartzkopf (Deutsches Elektronen-Synchrotron (DESY)) , Tim Snow (Diamond Light Source) , Himadri Gupta (Queen Mary, University of London) , Olga Shebanova (Diamond Light Source) , Konrad Schneider (Leibniz-Institut für Polymerforschung Dresden) , Baobao Chang (Leibniz-Institut für Polymerforschung Dresden)
Co-authored by industrial partner: No

Type: Conference Paper
Conference: Residual Stresses 2018
Peer Reviewed: No

State: Published (Approved)
Published: October 2018

Abstract: The major challenge of Research in bone surgery is to develop strategies to repair large bone defects. Bone grafting technique is the gold standard to fill and heal these kind of defects. This work address the evolution of the mechanical properties as regard to bone regeneration microstructure. Managing such a time dependent (different regeneration step) and spatially resolved (strain field across natural/reconstructed bone interface) process is achieved through a quantitative analysis of the mechanical strain distribution supported by the mineral part of bone architecture (hydroxyapatite – Hap) and crystal microstructural features (size distribution, spatial pattern). SAXS/WAXS (Small- and Wide- Angle X-ray Scattering) experiments will highlight strain distribution respectively in the reconstructed bone’s collagen fibrils and minerals, through mechanical state mapping over a surgically created defect under in situ tensile testing on samples harvested at different regeneration stages.

Journal Keywords: Bone regeneration; Mechanical properties; Small angle X-ray scattering; Wide angle X-ray scattering; Mineral crystals

Subject Areas: Biology and Bio-materials

Facility: Petra III