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Instruments / Technical Area	Publication Details	Published	Actions
DL-SAXS-Offline SAXS and Sample Environment Development	Natural polyphenol-containing gels against HSV-1 infection: a comparative study Mariaconcetta Sicurella , Maddalena Sguizzato , Paolo Mariani , Alessia Pepe , Anna Baldisserotto , Raissa Buzzi , Nicolas Huang , Fanny Simelière , Sam Burholt , Peggy Marconi , Elisabetta Esposito Nanomaterials 12 DOI: 10.3390/nano12020227 Diamond Proposal Number(s): [29797] Open Access Show Abstract ▼ Abstract: Herpes simplex virus type 1 infection commonly affects many people, causing perioral sores, as well as severe complications including encephalitis in immunocompromised patients. The main pharmacological approach involves synthetic antiviral drugs, among which acyclovir is the golden standard, often leading to resistant virus strains under long-term use. An alternative approach based on antiviral plant-derived compounds, such as quercetin and mangiferin, demonstrated an antiviral potential. In the present study, semisolid forms for cutaneous application of quercetin and mangiferin were designed and evaluated to treat HSV-1 infection. Phosphatidylcholine- and poloxamer-based gels were produced and characterized. Gel physical–chemical aspects were evaluated by rheological measurements and X-ray diffraction, evidencing the different thermoresponsive behaviors and supramolecular organizations of semisolid forms. Quercetin and mangiferin diffusion kinetics were compared in vitro by a Franz cell system, demonstrating the different gel efficacies to restrain the polyphenol diffusion. The capability of gels to control polyphenol antioxidant potential and stability was evaluated, indicating a higher stability and antioxidant activity in the case of quercetin loaded in poloxamer-based gel. Furthermore, a plaque reduction assay, conducted to compare the virucidal effect of quercetin and mangiferin loaded in gels against the HSV-1 KOS strain, demonstrated the suitability of poloxamer-based gel to prolong the polyphenol activity.	Jan 2022

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DL-SAXS-Offline SAXS and Sample Environment Development

Natural polyphenol-containing gels against HSV-1 infection: a comparative study