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Instruments / Technical Area	Publication Details	Published	Actions
I14-Hard X-ray Nanoprobe	Nuclear uptake of gold nanoparticles deduced using dual‐angle X‐ray fluorescence mapping Aaron Mcculloch , Lindsey Bennie , Jonathan A. Coulter , Helen O. Mccarthy , Brendan Dromey , David R. Grimes , Paul Quinn , Balder Villagomez-bernabe , Frederick Currell Particle & Particle Systems Characterization 6 DOI: 10.1002/ppsc.201900140 Diamond Proposal Number(s): [16931, 17932] Show Abstract ▼ Abstract: Studies into the cell nucleus' incorporation of gold nanoparticles (AuNPs) are often limited by ambiguities arising from conventional imaging techniques. Indeed, it is suggested that to date there is no unambiguous imaging evidence for such uptake in whole cells, particularly at the single nanoparticle level. This shortcoming in understanding exists despite the nucleus being the most important subcellular compartment in eukaryotes and gold being the most commonly used metal nanoparticle in medical applications. Here, dual‐angle X‐ray flouresence is used to show individually resolved nanoparticles within the cell nucleus, finding them to be well separated and 79% of the intranuclear population to be monodispersed. These findings have important implications for nanomedicine, illustrated here through a specific exemplar of the predicted enhancement of radiation effects arising from the observed AuNPs, finding intranuclear dose enhancements spanning nearly five orders of magnitude.	Jul 2019

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I14-Hard X-ray Nanoprobe

Nuclear uptake of gold nanoparticles deduced using dual‐angle X‐ray fluorescence mapping

Aaron Mcculloch , Lindsey Bennie , Jonathan A. Coulter , Helen O. Mccarthy , Brendan Dromey , David R. Grimes , Paul Quinn , Balder Villagomez-bernabe , Frederick Currell

Particle & Particle Systems Characterization 6

DOI: 10.1002/ppsc.201900140

Diamond Proposal Number(s): [16931, 17932]

Show Abstract ▼

Jul 2019