Diamond Publications - Search Results

Search Again...

These results only include publications that have been reviewed and processed by Diamond Light Source. To also view papers that have not yet been processed click here.

You can use the folder icon under Actions to collate papers as required. You can then click on View Folder in the left-hand navigation to review and/or download your folder.

One item found (0 items not approved).

Instruments / Technical Area	Publication Details	Published	Actions
I14-Hard X-ray Nanoprobe	Nuclear uptake of gold nanoparticles deduced using dual‐angle X‐ray fluorescence mapping Aaron Mcculloch , Lindsey Bennie , Jonathan A. Coulter , Helen O. Mccarthy , Brendan Dromey , David R. Grimes , Paul Quinn , Balder Villagomez-Bernabe , Frederick Currell Particle & Particle Systems Characterization 6 DOI: 10.1002/ppsc.201900140 Diamond Proposal Number(s): [16931, 17932] Open Access Show Abstract ▼ Abstract: Studies into the cell nucleus' incorporation of gold nanoparticles (AuNPs) are often limited by ambiguities arising from conventional imaging techniques. Indeed, it is suggested that to date there is no unambiguous imaging evidence for such uptake in whole cells, particularly at the single nanoparticle level. This shortcoming in understanding exists despite the nucleus being the most important subcellular compartment in eukaryotes and gold being the most commonly used metal nanoparticle in medical applications. Here, dual‐angle X‐ray flouresence is used to show individually resolved nanoparticles within the cell nucleus, finding them to be well separated and 79% of the intranuclear population to be monodispersed. These findings have important implications for nanomedicine, illustrated here through a specific exemplar of the predicted enhancement of radiation effects arising from the observed AuNPs, finding intranuclear dose enhancements spanning nearly five orders of magnitude.	Jul 2019

Instruments / Technical Area

Publication Details

Published

Actions

I14-Hard X-ray Nanoprobe

Nuclear uptake of gold nanoparticles deduced using dual‐angle X‐ray fluorescence mapping

Aaron Mcculloch , Lindsey Bennie , Jonathan A. Coulter , Helen O. Mccarthy , Brendan Dromey , David R. Grimes , Paul Quinn , Balder Villagomez-Bernabe , Frederick Currell

Particle & Particle Systems Characterization 6

DOI: 10.1002/ppsc.201900140

Diamond Proposal Number(s): [16931, 17932]