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Instruments / Technical Area	Publication Details	Published
I13-2-Diamond Manchester Imaging	X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue Marie-Christine Zdora , Joan Vila-Comamala , Georg Schulz , Anna Khimchenko , Alexander Hipp , Andrew C. Cook , Daniel Dilg , Christian David , Christian Grünzweig , Christoph Rau , Pierre Thibault , Irene Zanette Biomedical Optics Express 8 DOI: 10.1364/BOE.8.001257 Diamond Proposal Number(s): [13164] Open Access Show Abstract ▼ Abstract: The high-throughput 3D visualisation of biological specimens is essential for studying diseases and developmental disorders. It requires imaging methods that deliver high-contrast, high-resolution volumetric information at short sample preparation and acquisition times. Here we show that X-ray phase-contrast tomography using a single grating can provide a powerful alternative to commonly employed techniques, such as high-resolution episcopic microscopy (HREM). We present the phase tomography of a mouse embryo in paraffin obtained with an X-ray single-grating interferometer at I13-2 Beamline at Diamond Light Source and discuss the results in comparison with HREM measurements. The excellent contrast and quantitative density information achieved non-destructively and without staining using a simple, robust setup make X-ray single-grating interferometry an optimum candidate for high-throughput imaging of biological specimens as an alternative for existing methods like HREM.	Jan 2017
I13-1-Coherence	Novel methods for hard X-ray holographic lensless imaging M. Saliba , J. Bosgra , A. D. Parsons , U. H. Wagner , C. Rau , P. Thibault Microscopy And Microanalysis 22, 110 - 111 Microscopy & Microanalysis 2016 DOI: 10.1017/S1431927616001409 Open Access	Jul 2016
	Simulations of multi-contrast x-ray imaging using near-field speckles Marie- Christine Zdora , Pierre Thibault , Julia Herzen , Franz Pfeiffer , Irene Zanette Aip Conference Proceedings 1696 XRM 2014 DOI: 10.1063/1.4937510 Show Abstract ▼ Abstract: X-ray dark-field and phase-contrast imaging using near-field speckles is a novel technique that overcomes limitations inherent in conventional absorption x-ray imaging, i.e. poor contrast for features with similar density. Speckle-based imaging yields a wealth of information with a simple setup tolerant to polychromatic and divergent beams, and simple data acquisition and analysis procedures. Here, we present a simulation software used to model the image formation with the speckle-based technique, and we compare simulated results on a phantom sample with experimental synchrotron data. Thorough simulation of a speckle-based imaging experiment will help for better understanding and optimising the technique itself.	Jan 2016
	Simulations of x-ray speckle-based dark-field and phase-contrast imaging with a polychromatic beam Marie-Christine Zdora , Pierre Thibault , Franz Pfeiffer , Irene Zanette Journal Of Applied Physics 118 (11) DOI: 10.1063/1.4931145 Open Access Show Abstract ▼ Abstract: Following the first experimental demonstration of x-ray speckle-based multimodal imaging using a polychromatic beam [I. Zanette et al ., Phys. Rev. Lett. 112(25), 253903 (2014)], we present a simulation study on the effects of a polychromatic x-ray spectrum on the performance of this technique. We observe that the contrast of the near-field speckles is only mildly influenced by the bandwidth of the energy spectrum. Moreover, using a homogeneous object with simple geometry, we characterize the beam hardening artifacts in the reconstructed transmission and refraction angle images, and we describe how the beam hardening also affects the dark-field signal provided by speckle tracking. This study is particularly important for further implementations and developments of coherent speckle-based techniques at laboratory x-ray sources.	Sep 2015
	X-ray nanotomography using near-field ptychography Marco Stockmar , Maxime Hubert , Martin Dierolf , Bjorn Enders , Richard Clare , Sebastian Allner , Andreas Fehringer , Irene Zanette , Julie Villanova , Jérôme Laurencin , Peter Cloetens , Franz Pfeiffer , Pierre Thibault Optics Express 23 DOI: 10.1364/OE.23.012720 PMID: 26074526 Open Access Show Abstract ▼ Abstract: Propagation-based imaging or inline holography in combination with computed tomography (holotomography) is a versatile tool to access a sample’s three-dimensional (3D) micro or nano structure. However, the phase retrieval step needed prior to tomographic reconstruction can be challenging especially for strongly absorbing and refracting samples. Near-field ptychography is a recently developed phase imaging method that has been proven to overcome this hurdle in projection data. In this work we extend near-field ptychography to three dimensions and we show that, in combination with tomography, it can access the nano structure of a solid oxide fuel cell (SOFC). The quality of the resulting tomographic data and the structural properties of the anode extracted from this volume were compared to previous results obtained with holotomography. This work highlights the potential of 3D near-field ptychography for reliable and detailed investigations of samples at the nanometer scale, with important applications in materials and life sciences among others.	May 2015

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